Normal Pressure Hydrocephalus often causes problems such as memory impairment, gait instability and urinary disturbance. The current effect of drug treatment is not significant. Most patients need surgical drainage to achieve significant improvement and symptom improvement. However, because hydrocephalus is more common in elderly patients, and the patients often have different brain neurodegenerative diseases at the same time, and the pathological causes of hydrocephalus are still unknown, so these still have considerable variation in the degree of improvement of patients after surgery.

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We have developed a dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) technique that can analyze the integrity of the cerebrovascular barrier and the severity of damage. This method will help us evaluate the cerebrovascular barrier of hydrocephalus patients. At the same time, recording the changes in brain pressure and the analysis of the composition of the cerebrospinal fluid will likely help us discover the pathological mechanism of hydrocephalus and a better prognostic factor for drainage tube surgery.

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